Department of Orthopaedic Surgery

Dongzhu Ma, MD, PhD

  • Research Assistant Professor

Education & Training

  • MD, Anhui Medical University, Hefei, China
  • MS, Shandong Medical University, Jinan, China
  • PhD, Shanghai Medical College, Fudan University, Shanghai, China

Representative Publications

1. Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, Jiang Y. Rheb activates mTOR byantagonizing its endogenous inhibitor, FKBP38. Science. 2007 Nov 9;318(5852):977-80.

2. Ma D, Bai X, Guo S, Jiang Y. The switch I region of  Rheb is critical for its interaction with FKBP38. J Biol Chem. 2008 Sep 19; 283(38):25963-70.

3. Ma D, Bai X, Zou H, Lai Y, Jiang Y.  Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. J Biol Chem. 2010 Mar19;285(12):8621-7.

4. Ma D, Jasinska A, Kristoff J, Grobler JP, Turner T, Jung Y, Schmitt C, RaehtzK, Feyertag F, Martinez Sosa N, Wijewardana V, Burke DS, Robertson DL, Tracy R,Pandrea I, Freimer N, Apetrei C. SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations. PLoS Pathog. 2013 Jan; 9(1):e1003011.

5. Zou H, Lai Y, Zhao X, Yan G, Ma D, Cardenes N, Shiva S, Liu Y, Bai X, JiangY, Jiang Y. Regulation of mammalian target of rapamycin complex 1 by Bcl-2 andBcl-XL. J Biol Chem. 2013 Oct 4; 288(40):28824-30.

6. Wijewardana V, Kristoff J, Xu C, Ma D, Haret-Richter G, Stock JL, Policicchio BB, Mobley AD, Nusbaum R, Aamer H, Trichel A, Ribeiro RM, Apetrei C, Pandrea I. Kinetics of Myeloid Dendritic Cell Trafficking and Activation: Impact on Progressive,Nonprogressive and Controlled SIV Infections. PLoS Pathog. 2013;9(10):e1003600.

7. Ma D, Jasinska AJ, Feyertag F, Wijewardana V, Kristoff J, He T, Raehtz K, Schmitt CA, Jung Y, Cramer JD, Dione M, Antonio M, Tracy R, Turner T, Robertson DL,Pandrea I, Freimer N, Apetrei C. J Virol. 2014 May; 88(10):5687-705.

8. Kristoff J, Haret-Richter G, Ma D, Ribeiro RM, Xu C, Cornell E, Stock JL, HeT, Mobley AD, Ross S, Trichel A, Wilson C, Tracy R, Landay A, Apetrei C, PandreaI. Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. J Clin Invest. 2014 Jun; 124(6):2802-6.

9. Ma D, Xu C, Cillo AR, Policicchio B, Kristoff J, Haret-Richter G, Mellors JW, Pandrea I, Apetrei C. SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research. J Virol. 2015 Jun 1; 89(11):6155-60.

10. Pandrea I, Xu C, Stock JL, Frank DN, Ma D, Policicchio BB, He T, Kristoff J, Cornell E, Haret-Richter GS, Trichel A, Ribeiro RM, Tracy R, Wilson C, Landay AL, ApetreiC. Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques. Plos Pathogens.2016 Jan 14;12(1):e1005384.

11. Urish KL, DeMuth PW, Kwan BW, Craft DW, Ma D, Haider H, Tuan RS, Wood TK, Davis CM 3rd. Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials. Clin Orthop Relat Res. 2016 Feb 1.

Research Interests

My current research interest is focusing on periprosthetic joint infection (PJI). PJI is one of the most severe complications in total knee arthroplasty (TKA). Irrigation and debridement (I&D) with long-term antibiotics is the preferred method to manage PJI. The high failure rate of I&D is a result of the high tolerance of biofilm to antibiotics. How to disrupt the biofilm antibiotic tolerance is very important to clinical cure of PJI. I also have expertise in the pathogenesis and diversity of HIV/SIV infection. By using monkey models, we are studied the mechanisms of viral adaptation in new hosts and the events associated with viral emergence. We are also interested in testing new strategies aimed at reducing the virus in the reservoir and in boosting immune responses to clear the reactivated virus in SIV-infected monkeys.